Estrogen and Progesterone Receptors Expression in Resected Gallbladder from Gall bladder Carcinoma Cases
Abstract
Gallbladder carcinoma is most common malignancy of gartrointestinal tract (GIT) with poor diagnosis. Its prevalence is higher in females that too of northern India. This study aimed to identify the role of sex hormones in carcinoma gallbladder (CA GB). Resected 100 gall bladders of CA GB were examined immune-histo-chemicaly to find out ER and PR status with its association with its underlying histopathology. It was found in this study that PR status was observed in 36% of cases whereas ER status was positive in 2% of CA GB cases. It was also revealed that ER expression was specific and PR expression was more sensitive indicator in differentiating between benign and malignant carcinoma gall bladder.
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Introduction
Carcinoma is one of the most common malignancies of the GIT which has a dismal prognosis with a high incidence in North India. 1 Gallstone disease and gallbladder cancers are more frequently observed in females, especially multiparous females.2,3 Impaired gallbladder emptying during menses & pregnancy and higher prevalence of gallbladder diseases in females with high parity & prolonged fertility depict its association with female sex hormones. 2 Although few of studies showing the presence of estrogen receptor (ER) and progesterone receptor (PR) in benign4,5 and malignant6,7 gallbladder lesions but despite of the fact that Gallbladder carcinoma occurs more frequently in women than men, yet expression of the estrogen receptor (ER) and progesterone (PR) have not been much studied.. In the present study an immune-histo-chemical stain was applied to examine the expression of ER and PR status on resected gallbladder carcinomas aimed to study the ER and PR status of gallbladder carcinomas and its association with underlying histopathology.
Conclusion
Sex hormones like Estrogen and Progesterone influences gall bladder physiology and have a important role in gall bladder pathology. ER expression is being more specific and PR expression is being more sensitive indicator in malignant gall bladder carcinoma.