Evaluation of Wound healing activity of leaves of Passiflora foetida L in Streptozotocin-induced diabetes mellitus and Diabetic Excision Model
Abstract
The present study aimed to evaluate the wound healing activity of the leaves of Passiflora foetida L. in Streptozotocin (STZ)-induced diabetes mellitus in rats. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/Kg) in Wistar albino rats after overnight fasting. The diabetic rats were subjected to excision wounds on the dorsal side, which were treated with varying doses (100, 200, and 400 mg/Kg) of ethanol and ethyl acetate extracts of Passiflora foetida leaves for 21 days. The wound healing parameters, including wound contraction rate, epithelialization time, and scar area, were monitored and compared with the control group and standard treatment (Metformin 5 mg/Kg). The results revealed that both ethanol and ethyl acetate extracts exhibited significant wound healing activity, with the ethyl acetate extract (400 mg/Kg) showing the most potent effect. The extracts significantly enhanced wound closure, reduced epithelialization time, and promoted granulation tissue formation. The findings suggest that Passiflora foetida leaves possess substantial wound healing properties and could be a potential therapeutic candidate for the management of diabetic wounds.
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Introduction
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia, which often leads to complications such as delayed wound healing. Diabetic wounds are a major health concern, as they are prone to infection, poor healing, and prolonged recovery times. Traditional therapeutic approaches have limitations, thus prompting the need for alternative treatments that can promote wound healing in diabetic patients. Passiflora foetida L., commonly known as wild passionflower, has been traditionally used for its medicinal properties, including anti-inflammatory, antioxidant, and antimicrobial effects. Recent studies have highlighted its potential in promoting tissue regeneration and wound healing. However, the wound healing activity of Passiflora foetida in the context of diabetic wounds remains underexplored.
In this study, we aimed to evaluate the wound healing potential of Passiflora foetida leaf extracts in a rat model of Streptozotocin (STZ)-induced diabetes mellitus. By assessing key wound healing parameters, such as wound contraction, epithelialization time, and granulation tissue formation, this study seeks to determine the efficacy of Passiflora foetida leaf extracts in promoting wound healing in diabetic conditions. The findings could provide valuable insights into the therapeutic potential of Passiflora foetida for managing diabetic wounds.
Conclusion
The present study reveals that the ethyl acetate and ethanol extracts accelerate healing of wounds in diabetic patients. The results suggest that extracts may have a beneficial effect on wound healing phases. It is quite possible that the increase in the healing of wounds in diabetic rats is due to hypoglycemic activity (Rosenthal SP, 1968).